As a fourth-generation foaming agent with a low GWP value, HFO-1336mzz can replace HFC-245fa and HFC-365mfc in the field of rigid polyurethane foams. It is a preferred product due to its zero ODP, low GWP, non-flammability, high efficiency and thermal stability. Zero-ODP, Low GWP, Non-Flammable Working Fluid for Organic Rankine Cycles